Nature's Way DIM-plus Estrogen Metabolism Formula, 120 CapsulesSTROKED METABOLISM. Research shows diindolylmethane increases the level of "favorable" estrogens (2-hydroxyestrogen) while reducing the level of "less favorable" estrogens (16-hydroxyestrogen). *Greater absorption. The bioavailability of DIM-plus is superior to regular diindolylmethane and its unstable precursor, indole-..